diff --git a/ipn/ipnlocal/local.go b/ipn/ipnlocal/local.go
index 7d1f98b3e..c6de32288 100644
--- a/ipn/ipnlocal/local.go
+++ b/ipn/ipnlocal/local.go
@@ -4204,6 +4204,16 @@ func (b *LocalBackend) DeleteProfile(p ipn.ProfileID) error {
 	return b.resetForProfileChangeLockedOnEntry()
 }
 
+// DeleteProfiles removes all known profiles.
+func (b *LocalBackend) DeleteAllProfiles() error {
+	b.mu.Lock()
+	if err := b.pm.DeleteAllProfiles(); err != nil {
+		b.mu.Unlock()
+		return err
+	}
+	return b.resetForProfileChangeLockedOnEntry()
+}
+
 // CurrentProfile returns the current LoginProfile.
 // The value may be zero if the profile is not persisted.
 func (b *LocalBackend) CurrentProfile() ipn.LoginProfile {
diff --git a/ipn/ipnlocal/profiles.go b/ipn/ipnlocal/profiles.go
index 5d14c1d94..5c5c832a5 100644
--- a/ipn/ipnlocal/profiles.go
+++ b/ipn/ipnlocal/profiles.go
@@ -12,6 +12,7 @@
 	"runtime"
 	"time"
 
+	"golang.org/x/exp/maps"
 	"golang.org/x/exp/slices"
 	"tailscale.com/ipn"
 	"tailscale.com/tailcfg"
@@ -349,6 +350,21 @@ func (pm *profileManager) DeleteProfile(id ipn.ProfileID) error {
 	return pm.writeKnownProfiles()
 }
 
+// DeleteAllProfiles removes all known profiles and switches to a new empty
+// profile.
+func (pm *profileManager) DeleteAllProfiles() error {
+	metricDeleteAllProfile.Add(1)
+
+	for _, kp := range pm.knownProfiles {
+		if err := pm.store.WriteState(kp.Key, nil); err != nil {
+			return err
+		}
+	}
+	pm.NewProfile()
+	maps.Clear(pm.knownProfiles)
+	return pm.writeKnownProfiles()
+}
+
 func (pm *profileManager) writeKnownProfiles() error {
 	b, err := json.Marshal(pm.knownProfiles)
 	if err != nil {
@@ -512,9 +528,10 @@ func (pm *profileManager) migrateFromLegacyPrefs() error {
 }
 
 var (
-	metricNewProfile    = clientmetric.NewCounter("profiles_new")
-	metricSwitchProfile = clientmetric.NewCounter("profiles_switch")
-	metricDeleteProfile = clientmetric.NewCounter("profiles_delete")
+	metricNewProfile       = clientmetric.NewCounter("profiles_new")
+	metricSwitchProfile    = clientmetric.NewCounter("profiles_switch")
+	metricDeleteProfile    = clientmetric.NewCounter("profiles_delete")
+	metricDeleteAllProfile = clientmetric.NewCounter("profiles_delete_all")
 
 	metricMigration        = clientmetric.NewCounter("profiles_migration")
 	metricMigrationError   = clientmetric.NewCounter("profiles_migration_error")
diff --git a/ipn/ipnlocal/profiles_test.go b/ipn/ipnlocal/profiles_test.go
index a7ffee5c2..dc45ed6b5 100644
--- a/ipn/ipnlocal/profiles_test.go
+++ b/ipn/ipnlocal/profiles_test.go
@@ -164,6 +164,14 @@ func TestProfileManagement(t *testing.T) {
 	delete(wantProfiles, "tagged-node.2.ts.net")
 	wantCurProfile = "user@2.example.com"
 	checkProfiles(t)
+
+	t.Logf("Delete all")
+	pm.DeleteAllProfiles()
+	wantProfiles = map[string]ipn.PrefsView{
+		"": emptyPrefs,
+	}
+	wantCurProfile = ""
+	checkProfiles(t)
 }
 
 // TestProfileManagementWindows tests going into and out of Unattended mode on
diff --git a/ipn/localapi/localapi.go b/ipn/localapi/localapi.go
index 89366aa41..57928d6ba 100644
--- a/ipn/localapi/localapi.go
+++ b/ipn/localapi/localapi.go
@@ -1156,6 +1156,7 @@ func (h *Handler) serveTKADisable(w http.ResponseWriter, r *http.Request) {
 //   - GET /profiles/: list all profiles (JSON-encoded array of ipn.LoginProfiles)
 //   - PUT /profiles/: add new profile (no response). A separate
 //     StartLoginInteractive() is needed to populate and persist the new profile.
+//   - DELETE /profiles/: delete all profile (no response)
 //   - GET /profiles/current: current profile (JSON-ecoded ipn.LoginProfile)
 //   - GET /profiles/<id>: output profile (JSON-ecoded ipn.LoginProfile)
 //   - POST /profiles/<id>: switch to profile (no response)
@@ -1182,6 +1183,13 @@ func (h *Handler) serveProfiles(w http.ResponseWriter, r *http.Request) {
 				return
 			}
 			w.WriteHeader(http.StatusCreated)
+		case http.MethodDelete:
+			err := h.b.DeleteAllProfiles()
+			if err != nil {
+				http.Error(w, err.Error(), http.StatusInternalServerError)
+				return
+			}
+			w.WriteHeader(http.StatusCreated)
 		default:
 			http.Error(w, "use GET or PUT", http.StatusMethodNotAllowed)
 		}